Figure 3.

Dose schedule parameter sets that cure mutants when chemotherapy is started at different times. Each point represents a dose schedule parameter set that yield a 100% mutant cure rate and 0% crypt mortality rate when tested over 50 stochastic replicates. The duration of chemotherapy (in simulation time-steps) is represented on the x-axis; the interval between doses (in simulation time-steps) is represented on the y-axis; cytotoxic lethality factor is represented on the z-axis. Points are color-coded based on the average time to cure a crypt of mutant cells, with red representing a treatment schedule that quickly eliminates the mutant cells and dark blue representing a treatment which takes longer to eliminate mutant cells. (A): successful parameter sets for chemotherapy that is initiated when mutant cells make up 20% of the total crypt population; (B): successful parameter sets for chemotherapy that is initiated when mutant cells make up 40% of the total crypt population. (C): comparison of parameter sets in A and B. Points shaded in red are those which are unique to the set of simulations that initiate chemotherapy when mutant cells compose 20% of the crypt; points shaded in blue are those which are unique to the set of simulations that initiate chemotherapy when mutant cells compose 40% of the crypt; points shaded in green are those which are shared between the set of simulations that initiate chemotherapy when mutant cells compose 20% of the crypt and the set of simulations that initiate chemotherapy when mutant cells compose 40% of the crypt.