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. 2019 Jan 14;17:1. doi: 10.1186/s12959-018-0190-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Predictive performance of circulating histone H3 levels for mortality is higher than that of conventional inflammatory markers. ROC curves for serum histone H3 levels, cell-free DNA (cfDNA) levels, CRP levels, and white blood cell (WBC) counts on day 1 are shown. The AUCs for histone H3 levels, cfDNA levels, CRP levels, and WBC counts were 0.73, 0.63, 0.58, and 0.56, respectively