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. 2019 Jan 7;8:645. doi: 10.3389/fonc.2018.00645

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Copyright © 2019 Tessoulin, Papin, Gomez-Bougie, Bellanger, Amiot, Pellat-Deceunynck and Chiron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BCL2-family is strongly deregulated in the landscape of B-cell malignancies. (A) Heat-map of Bcl-2 gene expression profiles among B-cell malignancies. The color corresponds to the intensity of the median gene expression. Blue indicates lower and red higher transcript abundance. MCL, Mantle Cell Lymphoma; BL, Burkitt lymphoma; DLBCL, Diffuse Large B-cell Lymphoma; FL, Follicular Lymphoma; BPLL, B-cell Prolymphocytic Leukemia; CLL, Chronic lymphocytic leukemia; HCL, Hairy Cell Lymphoma; MALT, mucosa-associated lymphoid tissue lymphoma; SMZL, Splenic Marginal Zone Lymphoma; BMPC, Bone Marrow Plasma Cell, MM: multiple Myeloma. (B) Expression of BCL2, BCL2A1, and BCL2L11 in the different B-cell malignancies compared to their respective control. Wilcoxon-Mann-Whitney tests. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001. (C) Representation of the individual factor map of each sample for the PCA and according to the two first dimensions. Colored ellipses are drawn around the mean of the group (= barycenter), with the 95% confidence interval of the mean in the corresponding plan. BCL2 is coding for Bcl-2 protein, BCL2L1 for Bcl-xL, MCL1 for Mcl-1, BCL2L2 for Bcl-w, BCL2A1 for Bfl1, BIK for Bik, PMAIP1 for Noxa, BMF for Bmf, BID for Bid, BCL2L11 for Bim, BAX for Bax, and BAK1 for Bak.