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. 2019 Jan 7;8:645. doi: 10.3389/fonc.2018.00645

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Copyright © 2019 Tessoulin, Papin, Gomez-Bougie, Bellanger, Amiot, Pellat-Deceunynck and Chiron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular subtypes display differential expression of the BCL2-family. (A) left; Heat-map of BCL2-family expression profile comparing PB MCL according to SOX11 gene expression (right). MCL1 and BIK expression in the two molecular subgroups. (B) left; Heat-map of BCL2-family expression profile comparing the different subtypes of DLBCL: GCB (germinal center B cell, ABC (activated B-cell) and PMBL (Primary mediastinal B-cell lymphoma). right; Gene expression of BCL2L1, BCL2, BID, and BMF for the three subtypes of DLBCL. (C) Representation of the individual factor map for the PCA and according to the two first dimensions of multiple myeloma samples and their respective correlation circle. Colored ellipses are drawn around the mean of the group (= barycenter), with the 95% confidence interval of the mean in the corresponding plan. (D) BCL2L2, BCL2L11, and BMF expression in the different multiple myeloma subtypes. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001.