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. 2019 Jan 7;8:645. doi: 10.3389/fonc.2018.00645

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Copyright © 2019 Tessoulin, Papin, Gomez-Bougie, Bellanger, Amiot, Pellat-Deceunynck and Chiron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(BCL2+BCL2L11+BAX)/BCL2L1 ratio predicts response to Bcl2 specific BH3 mimetic. (A) Evaluation of the (BCL2+BCL2L11+BAX)/BCL2L1 ratio for the different B-cell malignancies associated to ORR and PFS of patients treated with venetoclax-monotherapy when available. (B,C) Evaluation of the (BCL2 + BCL2L11 + BAX)/BCL2L1 ratio for the different subtypes of (B) MM and (C) MCL and DLBCL. (D) Evaluation of the (BCL2 + BCL2L11 + BAX)/BCL2L1 ratio for the different subtypes of FL and MALT. (E) Evaluation of the (BCL2 + BCL2L11 + BAX)/BCL2L1 ratio for MCL, FL, CLL, SMZL according to their tissue localization (peripheral blood, PB, lymph nodes, LN, spleen, SPL). ^*p < 0.05, ^**p < 0.01, ^****p < 0.0001.