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. 2019 Jan 7;12:516. doi: 10.3389/fncel.2018.00516

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Copyright © 2019 Fan, Song, Wang, Li, Yang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Curcumin rescues CUMS-induced depression-like behaviors in rats. (A) Experimental design: schematic figure of the treatment protocol. (B) Chronic treatment of curcumin (40 mg/kg) reversed the decreases in percent of sucrose consumption of CUMS-exposed rats. (C) Curcumin treatment decreased immobility times and increased swimming times of CUMS-exposed rats in forced swim test. All data are presented as means ± SEM (N = 18/group). ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 CUMS vs. Control group (non-stressed). #P < 0.05, ##P < 0.01, ###P < 0.001 Cur + CUMS vs. CUMS group (Cur, Curcumin).