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. 2019 Jan 7;12:516. doi: 10.3389/fncel.2018.00516

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Copyright © 2019 Fan, Song, Wang, Li, Yang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Curcumin ameliorated neuronal apoptosis within the vmPFC as induced by CUMS exposure. (A) Curcumin treatment decreased the number of TUNEL positive apoptotic cells (top, indicated by the arrows) and NeuN positive cells (bottom, indicated by the arrows) in the vmPFC of CUMS-exposed rats. Scale bar is 20 μm. (B) Histograms showing the increased TUNEL positive cells were significantly attenuated by curcumin pretreatment. (C) Histograms showing the decreased NeuN positive cells was significantly attenuated by curcumin pretreatment. (D) Representative electron micrograph of vmPFC neuronal ultrastructure. Arrows indicate nuclear chromatin aggregation, condensation and margination. Scale bar is 2 μm. Curcumin significantly ameliorated apoptosis of vmPFC neurons in CUMS-exposed rats. N = 6/group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 CUMS vs. Control group (non-stressed). #P < 0.05, ##P < 0.01, ###P < 0.001 Cur + CUMS vs. CUMS group.