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. 2019 Jan 7;12:516. doi: 10.3389/fncel.2018.00516

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Copyright © 2019 Fan, Song, Wang, Li, Yang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of IL-1β within the vmPFC leads to neuronal apoptosis within the vmPFC of normal wild type rats. (A) TUNEL positive apoptotic cells (indicated by the arrows) in vmPFC regions infected with AAV-IL-1β. (B) Histograms showing the increased TUNEL positive cells caused by AAV-IL-1β infusion were significantly attenuated by curcumin treatment. (C) Nuclear chromatin abnormalities in vmPFC neurons infected with AAV-IL-1β. Arrows indicate nuclear chromatin aggregation, condensation and margination. N = 6/group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 WT + AAV-IL-1β vs. WT rats. #P < 0.05, ##P < 0.01, ###P < 0.001 WT + AAV-IL-1β + Cur vs. WT + AAV-IL-1β.