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. 2019 Jan 7;12:516. doi: 10.3389/fncel.2018.00516

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Copyright © 2019 Fan, Song, Wang, Li, Yang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knocking-down of IL-1β in the vmPFC decreased neuronal apoptosis within the vmPFC of stressed rats. (A) TUNEL positive apoptotic cells (indicated by the arrows) in vmPFC regions infected with AAV-IL-1β RNAi construct. (B) Histograms showing the decreased TUNEL positive cells caused by AAV-IL-1β RNAi construct infusion. (C) nuclear chromatin abnormalities in vmPFC neurons infected with the AAV-IL-1β RNAi construct. Arrows indicate nuclear chromatin aggregation, condensation and margination. N = 6/group. ^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001 Stressed rats vs. WT rats. #P < 0.05, ##P < 0.01, ###P < 0.001 S+AAV-IL-1β RNAi vs. Stressed rats.