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. 2018 Dec 30;2018:4902941. doi: 10.1155/2018/4902941

Table 1.

The drug susceptibility results of 37 RGM isolates.

Antimicrobial Agent MIC(μg/ml) M. abscessus (n=20) MIC(μg/ml) M. fortuitum (n=17)
range MIC 90 R I S range MIC 90 R I S
Macrolides
 CLR 0.0625-64 32 4 (20%)/7(35%) 0 (0%)/0 (0%) 16 (80%)/13(65%) 32-64 32 16 (94%)/17(100%) 0 (0%)/0 (0%) 1 (6%)/0(0%)
 AZM 0.125-128 2 2 (10%) 0 (0%) 18 (90%) 8-128 32 17 (100%) 0 (0%) 0 (0%)
Rifamycins
 RFB 0.5-8 4 15 (75%) - 5 (25%) 1-8 4 16 (94%) - 1 (6%)
 RIF 64-256 128 20 (100%) - 0 (0%) 32-256 128 17 (100%) - 0 (0%)
Aminoglycosides
 STR 32-128 64 20 (100%) - 0 (0%) 16-128 32 17 (100%) - 0 (0%)
 GEN 0.5-64 32 14 (70%) 1 (5%) 5 (25%) 4-64 32 4 (24%) 9 (53%) 4 (24%)
 KAN 4-16 8 16 (80%) - 4 (20%) 4-32 16 16 (94%) - 1 (6%)
 TOB 2-32 8 12 (60%) 3 (15%) 5 (25%) 16-64 16 0 (0%) 0 (0%) 17 (100%)
 NEO 0.5-64 16 13 (65%) - 7 (35%) 2-8 2 0 (0%) - 17 (100%)
 AMK 0.5-64 32 2 (10%) 9 (45%) 9 (45%) 2-8 4 0 (0%) 0 (0%) 17 (100%)
Fluoroquinolones
 MXF 0.0625-16 8 19 (95%) 0 (0%) 1 (5%) 0.0625-8 2 10 (59%) 5 (29%) 2 (12%)
 CIP 0.125-128 64 19 (95%) 0 (0%) 1 (5%) 0.125-256 128 8 (47%) 0 (0%) 9 (53%)
 LVX 0.125-32 16 19 (95%) 0 (0%) 1 (5%) 0.125-32 16 7 (41%) 0 (0%) 10 (59%)
Cephalosporins
 FOX 16-256 64 2 (10%) 10 (50%) 8 (40%) 16-128 32 15 (88%) 0 (0%) 2 (12%)
 CMZ 2-256 128 11 (55%) 5 (25%) 4 (20%) 2-64 8 2 (12%) 0 (0%) 15 (88%)
Tetracyclines
 TCY 2-256 64 9 (45%) 3 (15%) 8 (40%) 1-8 4 0 (0%) 12 (70%) 5 (30%)
 DOX 0.5-256 128 14 (70%) 2 (10%) 4 (20%) 0.5-256 128 15 (88%) 0 (0%) 2 (12%)
 MNO 0.125-128 64 11 (55%) 3 (15%) 6 (30%) 0.25-32 16 14 (82%) 1 (6%) 2 (12%)
Glycylcycline
 TGC 0.0625-16 8 8 (40%) 6 (30%) 6 (30%) 0.0625-4 0.5 0 (0%) 1 (6%) 16 (94%)
Sulfonamides
 SOX 2-256 128 18 (90%) - 2 (10%) 16-256 128 14 (82%) - 3 (18%)
Carbapenems
 IMP 1-256 64 13 (65%) 2 (10%) 5 (25%) 2-32 16 2 (12%) 12 (70%) 3 (18%)
Oxazolidinones
 LNZ 2-128 16 3 (15%) 1 (5%) 16 (80%) 8-32 16 3 (18%) 12 (70%) 2 (12%)
Lincosamides
 CLI 8-256 128 20 (100%) 0 (0%) 0 (0%) 256 256 17 (100%) 0 (0%) 0 (0%)
Penicillins
 OXA 256 256 20 (100%) - 0 (0%) 256 256 17 (100%) - 0 (0%)
Polypeptides
 TEC 0.5-256 128 17 (85%) 1 (5%) 2 (10%) 128-256 128 17 (100%) 0 (0%) 0 (0%)
 VAN 256 256 20 (100%) 0 (0%) 0 (0%) 256 256 17 (100%) 0 (0%) 0 (0%)
Others
 CFZ 0.25-128 32 19 (95%) - 1 (5%) 0.125-128 0.25 10 (59%) - 7 (41%)
 EMB 256 256 20 (100%) - 0 (0%) 256 256 17 (100%) - 0 (0%)
 INH 8-256 16 20 (100%) - 0 (0%) 8-16 8 17 (100%) - 0 (0%)
 ETH 16-256 64 20 (100%) - 0 (0%) 4-256 32 16 (94%) - 1 (6%)

(a) CLR= clarithromycin, AZM= azithromycin, RFB= rifabutin, RIF= rifampin, STR= streptomycin, GEN= gentamycin, KAN= kanamycin, TOB= tobramycin, NEO= neomycin, AMK= amikacin, MXF= moxifloxacin, CIP= ciprofloxacin, LVX= levofloxacin, FOX= cefoxitin, CMZ= cefmetazole, TCY= tetracycline, DOX= doxycycline, MNO= minocycline, TGC= tigecycline, SOX= sulfamethoxazole, IMP= imipenem, LNZ= linezolid, CLI= clindamycin, OXA= oxacillin, TEC= teicoplanin, VAN= vancomycin, CFZ= clofazimine, EMB= ethambutol, INH= isoniazid, and ETH= ethionamide.

(b) “-“ indicates data not available.

(c) For CLR, each resistance and susceptible rate has two data. The first is the MIC result for 3 days and the second is the MIC result for 14 days.