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Fractional polynomial plots of predicted PTH concentration for serum 25(OH)D concentrations in patients with and without TDF-containing ART. Black dotted lines demonstrate that the degree of PTH suppression as found in non-TDF-treated patients at a threshold of 20 ng/mL (vitamin D deficiency) is only found at much higher 25(OH)D concentrations in PLWH on TDF-ART.
