Table 1.
Patient characteristics of groups with and without TDF-containing ART.
| Unit | TDF (N=564) | Non-TDF (N=438) | P value | |
|---|---|---|---|---|
| Age | Years (IQR) | 47 (38–53) | 50 (42–58) | <0.001 |
| Male | N (%) | 429 (76.1) | 357 (81.5) | 0.038 |
| African ethnicity | N (%) | 91 (16.1) | 33 (7.5) | <0.001 |
| Missing data | N (%) | 1 (0.2) | 0 (0.0) | |
| Creatinine (S) | mg/dL (IQR) | 0.95 (0.82–1.07) | 1.00 (0.86–1.11) | <0.001 |
| 25(OH)D (S) | ng/mL (IQR) | 23.0 (14.9–31.1) | 23.6 (16.5–30.4) | 0.366 |
| 25(OH)D < 20 ng/mL | N (%) | 230 (40.8) | 165 (37.7) | 0.998 |
| Total calcium (S) | mmol/L (IQR) | 2.22 (2.16–2.28) | 2.25 (2.18–2.31) | <0.001 |
| Albumin-corrected calcium | mmol/L (IQR) | 2.20 (2.14–2.26) | 2.22 (2.17–2.28) | <0.001 |
| Albumin-corrected calcium < 2.12 mmol/L | N (%) | 96 (17.0) | 43 (9.8) | 0.001 |
| Phosphate | mg/dL (IQR) | 3.4 (3.0–3.8) | 3.4 (3.0–3.8) | 0.392 |
| PTH (S) | pg/mL (IQR) | 44.3 (29.9–61.9) | 33.7 (22.5–49.3) | <0.001 |
| Elevated PTH | N (%) | 121 (21.5) | 46 (10.5) | <0.001 |
| C-terminal telopeptides of collagen type 1 (S) | µg/L (IQR) | 0.38 (0.25–0.52) | 0.28 (0.20–0.42) | <0.001 |
| Elevated C-terminal telopeptides of collagen type 1 | N (%) | 49 (8.7) | 25 (5.7) | 0.074 |
| Alkaline phosphatase (S) | U/L (IQR) | 83 (68–101) | 74 (61–93) | <0.001 |