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. 2019 Jan 10;12:1–10. doi: 10.2147/TACG.S187922

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© 2019 Mancina et al. This work is published and licensed by Dove Medical Press Limited

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Cumulative incidence of alcoholic cirrhosis in individuals according to (A) PNPLA3 I148M genotype and (B) CD14 C159T genotype. Alcohol years indicate the duration of at-risk alcohol consumption (daily intake of ≥3 alcohol units). It corresponds to the number of years from age at onset of at-risk alcohol consumption to age at cirrhosis onset or final follow-up without cirrhosis, measuring hence the period of exposure to the pathogenic agent. The number at the bottom indicates the number of individuals at risk at the following time points: 0, 10, 20, 30, and 40 years.

Abbreviations: PNPLA3 II, individuals with two 148I alleles; MM, individuals with two 148M alleles; IM, heterozygotes; CD14 CC, individuals with two 159C alleles; TT, individuals with two 159T alleles; CT, heterozygotes.