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. 2019 Jan 7;9:3252. doi: 10.3389/fmicb.2018.03252

Figure 2.

Figure 2

Anti-ZIKV drugs targeting the different steps in the viral life cycle. Emricasan targets caspase-3 activity to prevent cell death. Z2 peptide targets ZIKV cell entry. 25-hydroxycholesterol and chloroquine interfere with lipid homeostasis and autophagy to disrupt viral particle release after endocytosis. Temoporfin, nitazoxanide, niclosamide, and viperin block NS2B/NS3 protease activity to prevent viral replication. Sofosbuvir, merimepodib, N-(4-hydrophenyl) retinamide, 7-deaza-2′-C-methyladenosine, NITD008, BCX4430, and ribavarin block ZIKV NS5 polymerase activity to prevent viral replication. Ribavarin and merimepodib block IMPDH, an enzyme involved in de novo synthesis of guanine nucleotides. Niclosamide, EGCG, and cavinafungin block CDKs and prevent viral replication.