Figure 2.

Expression profiles of altered copy numbers of histone lysine methyltransferase (HKMT) in samples of prostate cancer according to Gleason scores. (A) The pheatmap package in R shows that increasing copy number alteration (CNA) events of 51 histone methyltransferases (HMTs) in prostate cancer samples, with a Gleason score of 6 to 9, were significantly associated with the clinical stage. (B) A histogram shows the effect on HMT expression levels due to changes in gene copy numbers. The y-axis represents the proportion of genes expressed (higher or lower) associated with different types of copy number alterations. (C) A histogram shows that the average CNA events of HMTs in each sample are incrementally increased with an increase in Gleason score.