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. 2019 Jan 7;25:193–239. doi: 10.12659/MSM.912294

Supplementary Table 8A.

Summary of multivariate analysis of RFS for amplification of 21 HMTs in prostate cancer.

Multivariate Age Pathology T Gleason score AR expression EHMT1 amplification
Coefficient −0.017 0.788 0.988 0.198 0.646
Hazard ratio 0.983 2.198 2.687 1.219 1.908
95%CI Lower 0.948 1.139 1.59 0.767 1.112
Higher 1.019 4.241 4.538 1.938 3.274
p-Value 0.35 0.0189 0.0002 0.4019 0.0191
Multivariate Age Pathology T Gleason score AR expression EHMT2 amplification
Coefficient −0.004 0.717 0.906 0.239 0.666
Hazard ratio 0.996 2.049 2.476 1.27 1.947
95%CI Lower 0.961 1.089 1.473 0.795 0.83
Higher 1.033 3.854 4.16 2.029 4.57
p-Value 0.8407 0.0261 0.0006 0.3177 0.1257
Multivariate Age Pathology T Gleason score AR expression PRDM12 amplification
Coefficient −0.007 0.676 0.921 0.325 0.665
Hazard ratio 0.993 1.967 2.512 1.384 1.945
95%CI Lower 0.959 1.037 1.492 0.871 1.125
Higher 1.029 3.73 4.23 2.2 3.362
p-Value 0.7062 0.0383 0.0005 0.1691 0.0172
Multivariate Age Pathology T Gleason score AR expression PRDM14 amplification
Coefficient −0.007 0.757 0.984 0.226 0.329
Hazard ratio 0.993 2.131 2.675 1.254 1.39
95%CI Lower 0.959 1.136 1.61 0.797 0.875
Higher 1.029 3.999 4.446 1.972 2.209
p-Value 0.7034 0.0184 0.0001 0.3271 0.1637
Multivariate Age Pathology T Gleason score AR expression PRDM15 amplification
Coefficient −0.005 0.654 0.952 0.132 0.436
Hazard ratio 0.995 1.923 2.59 1.141 1.546
95%CI Lower 0.958 1.019 1.534 0.704 0.743
Higher 1.033 3.629 4.372 1.849 3.22
p-Value 0.7942 0.0436 0.0004 0.5931 0.2442
Multivariate Age Pathology T Gleason score AR expression PRDM4 amplification
Coefficient −0.006 0.779 0.923 0.263 0.867
Hazard ratio 0.994 2.179 2.517 1.301 2.379
95%CI Lower 0.959 1.164 1.502 0.801 1.143
Higher 1.031 4.082 4.219 2.112 4.953
p-Value 0.7471 0.0149 0.0005 0.2881 0.0205
Multivariate Age Pathology T Gleason score AR expression SETD1A amplification
Coefficient −0.015 0.872 0.893 0.073 0.391
Hazard ratio 0.985 2.392 2.442 1.076 1.479
95%CI Lower 0.947 1.217 1.43 0.662 0.722
Higher 1.024 4.702 4.171 1.749 3.029
p-Value 0.4491 0.0114 0.0011 0.7672 0.2851
Multivariate Age Pathology T Gleason score AR expression SETD1B amplification
Coefficient −0.003 0.796 0.907 0.152 1.218
Hazard ratio 0.997 2.216 2.477 1.164 3.381
95%CI Lower 0.961 1.179 1.467 0.711 1.55
Higher 1.034 4.166 4.18 1.906 7.372
p-Value 0.8521 0.0135 0.0007 0.5451 0.0022
Multivariate Age Pathology T Gleason score AR expression SETD8 Amplification
Coefficient 0 0.8 0.898 0.2 0.97
Hazard ratio 1 2.226 2.456 1.221 2.638
95%CI Lower 0.964 1.182 1.453 0.747 1.101
Higher 1.038 4.191 4.152 1.996 6.323
p-Value 0.9897 0.0132 0.0008 0.4256 0.0296
Multivariate Age Pathology T Gleason score AR expression SETDB1 amplification
Coefficient −0.009 0.812 0.941 0.158 0.701
Hazard ratio 0.991 2.253 2.563 1.171 2.016
95%CI Lower 0.957 1.209 1.559 0.744 1.062
Higher 1.027 4.2 4.214 1.842 3.826
p-Value 0.6255 0.0106 0.0002 0.4956 0.0319
Multivariate Age Pathology T Gleason score AR expression SMYD1 amplification
Coefficient −0.004 0.788 0.906 0.15 1.423
Hazard ratio 0.996 2.198 2.475 1.162 4.149
95%CI Lower 0.959 1.139 1.443 0.716 1.844
Higher 1.034 4.243 4.244 1.885 9.336
p-Value 0.8369 0.0189 0.001 0.5434 0.0006
Multivariate Age Pathology T Gleason score AR expression SMYD2 amplification
Coefficient 0 0.798 0.955 0.181 0.77
Hazard ratio 1 2.221 2.6 1.198 2.159
95%CI Lower 0.965 1.16 1.556 0.751 1.026
Higher 1.037 4.253 4.343 1.91 4.546
p-Value 0.9835 0.0161 0.0003 0.4483 0.0426
Multivariate Age Pathology T Gleason score AR expression SMYD5 Amplification
Coefficient 0.004 0.745 0.929 0.163 1.274
Hazard ratio 1.004 2.106 2.532 1.177 3.574
95%CI Lower 0.967 1.119 1.484 0.729 1.595
Higher 1.042 3.966 4.32 1.901 8.01
p-Value 0.8462 0.0211 0.0007 0.5045 0.002
Multivariate Age Pathology T Gleason score AR expression SUV420H1 amplification
Coefficient −0.006 0.835 0.897 0.155 0.394
Hazard ratio 0.994 2.304 2.452 1.168 1.483
95%CI Lower 0.96 1.237 1.48 0.742 0.809
Higher 1.03 4.289 4.064 1.838 2.718
p-Value 0.7365 0.0085 0.0005 0.5016 0.2028
Multivariate Age Pathology T Gleason score AR expression SUV420H2 amplification
Coefficient −0.014 0.885 0.927 0.072 0.422
Hazard ratio 0.986 2.422 2.528 1.075 1.524
95%CI Lower 0.949 1.263 1.51 0.664 0.673
Higher 1.025 4.642 4.231 1.741 3.455
p-Value 0.4852 0.0077 0.0004 0.7691 0.3126
Multivariate Age Pathology T Gleason score AR expression WHSC1 amplification
Coefficient −0.014 0.786 1.051 0.152 0.439
Hazard ratio 0.986 2.194 2.86 1.165 1.551
95%CI Lower 0.951 1.142 1.702 0.733 0.732
Higher 1.022 4.218 4.806 1.851 3.286
p-Value 0.4366 0.0184 0.0001 0.5191 0.2522
Multivariate Age Pathology T Gleason score AR expression WHSC1L1 amplification
Coefficient 0.001 0.486 1.027 0.21 0.565
Hazard ratio 1.001 1.627 2.792 1.233 1.76
95%CI Lower 0.956 0.709 1.378 0.686 0.946
Higher 1.049 3.732 5.657 2.216 3.272
p-Value 0.95 0.251 0.0044 0.4836 0.0742