Supplementary Table 8C.

Summary of multivariate analysis of RFS for higher promotor methylation of 6 HMTs in prostate cancer.

Multivariate		Age	Pathology T	Gleason score	AR expression	PRDM14 high_meth
Coefficient		−0.009	0.785	0.916	0.188	0.32
Hazard ratio		0.991	2.193	2.498	1.207	1.377
95%CI	Lower	0.957	1.174	1.508	0.769	0.823
	Higher	1.027	4.095	4.139	1.894	2.303
p-Value		0.6314	0.0137	0.0004	0.4131	0.223
Multivariate		Age	Pathology T	Gleason score	AR expression	PRDM13 high_meth
Coefficient		−0.006	0.791	0.971	0.171	0.317
Hazard ratio		0.994	2.206	2.641	1.187	1.373
95%CI	Lower	0.96	1.182	1.608	0.755	0.86
	Higher	1.029	4.119	4.338	1.864	2.19
p-Value		0.7279	0.013	0.0001	0.4581	0.1839
Multivariate		Age	Pathology T	Gleason score	AR expression	PRDM6 high_meth
Coefficient		−0.004	0.816	0.967	0.191	0.079
Hazard ratio		0.996	2.262	2.631	1.211	1.082
95%CI	Lower	0.962	1.208	1.594	0.771	0.675
	Higher	1.031	4.235	4.341	1.901	1.734
p-Value		0.8298	0.0108	0.0002	0.4059	0.7441
Multivariate		Age	Pathology T	Gleason score	AR expression	PRDM8 high_meth
Coefficient		−0.004	0.826	0.933	0.184	0.324
Hazard ratio		0.996	2.285	2.542	1.201	1.383
95%CI	Lower	0.963	1.227	1.542	0.766	0.869
	Higher	1.031	4.257	4.189	1.883	2.199
p-Value		0.8314	0.0092	0.0003	0.4236	0.1712
Multivariate		Age	Pathology T	Gleason score	AR expression	KMT2B high_meth
Coefficient		−0.003	0.86	0.897	0.229	−0.417
Hazard ratio		0.997	2.363	2.452	1.257	0.659
95%CI	Lower	0.963	1.274	1.486	0.8	0.409
	Higher	1.033	4.382	4.045	1.975	1.061
p-Value		0.8776	0.0064	0.0004	0.3215	0.086
Multivariate		Age	Pathology T	Gleason score	AR expression	NSD1 High_meth
Coefficient		−0.006	0.852	0.889	0.161	0.547
Hazard ratio		0.994	2.345	2.432	1.175	1.728
95%CI	Lower	0.961	1.26	1.476	0.749	1.06
	Higher	1.028	4.364	4.009	1.843	2.818
p-Value		0.7268	0.0071	0.0005	0.4839	0.0284