Supplementary Table 1.
Summary of identified human HMTs and their histone substrates.
| Official symbol | Other aliases | Gene ID | Gene location | Histone substrates |
|---|---|---|---|---|
| ASH1L | KMT2H; ASH1L1 | 55870 | 1q22 | H3K4me1/3, H3K36me2 |
| DOT1L | DOT1; KMT4 | 84444 | 19p13.3 | H3K79me1/2/3 |
| EHMT1 | GLP1; KMT1D | 79813 | 9q34.3 | H3K9me1/2 |
| EHMT2 | G9A; KMT1C | 10919 | 6p21.31 | H3K9me1/2 |
| EZH1 | KMT6B | 2145 | 17q21.2 | H3K27me2/3 |
| EZH2 | KMT6A | 2146 | 7q36.1 | H3K27me2/3 |
| KMT2A | MLL | 4297 | 11q23.3 | H3K4me1/2/3 |
| KMT2B | MLL2 | 9757 | 19q13.12 | H3K4me1/2/3 |
| KMT2C | MLL3 | 58508 | 7q36.1 | H3K4me1/2/3 |
| KMT2D | MLL4 | 8085 | 12q13.12 | H3K4me1/2/3 |
| KMT2E | MLL5 | 55904 | 7q22.3 | H3K4 |
| MECOM | PRDM3; MDS1-EVI1 | 2122 | 3q26.2 | H3K9me1 |
| NSD1 | KMT3B | 64324 | 5q35.2 | H3K36me1/2 |
| PRDM1 | BLIMP16 | 639 | 6q21 | |
| PRDM10 | PFM7 | 56980 | 11q24.3 | |
| PRDM11 | PFM8 | 56981 | 11p11.2 | |
| PRDM12 | PFM9 | 59335 | 9q34.12 | |
| PRDM13 | PFM10 | 59336 | 6q16.2 | |
| PRDM14 | PFM11 | 63978 | 8q13.3 | |
| PRDM15 | PFM15 | 63977 | 21q22.3 | |
| PRDM16 | MEL1; PFM13 | 63976 | 1p36.32 | H3K9me1 |
| PRDM2 | RIZ; KMT8 | 7799 | 1p36.21 | H3K9me1/2/3 |
| PRDM4 | PFM1 | 11108 | 12q23.3 | |
| PRDM5 | PFM2 | 11107 | 4q27 | H3K9me2 |
| PRDM6 | 93166 | 5q23.2 | ||
| PRDM7 | PFM4; ZNF910 | 11105 | 16q24.3 | |
| PRDM8 | PFM5 | 56978 | 4q21.21 | H3k9me3 |
| PRDM9 | PFM6; MEISETZ | 56979 | 5p14.2 | H3K4me3 |
| SETD1A | KMT2F; SET1A | 9739 | 16p11.2 | H3K4me1/2/3 |
| SETD1B | KMT2G; SET1B | 23067 | 12q24.31 | H3K4me1/2/3 |
| SETD2 | HYPB; SET2 | 29072 | 3p21.31 | H3K36me1/2/3 |
| SETD3 | C14orf154 | 84193 | 14q32.2 | |
| SETD4 | C21orf18 | 54093 | 21q22.12 | |
| SETD5 | 55209 | 3p25.3 | ||
| SETD6 | 79918 | 16q21 | ||
| SETD7 | KMT7; SET7/9 | 80854 | 4q31.1 | H3K4me1 |
| SETD8 | KMT5A; PR-SETD7 | 387893 | 12q24.31 | H4K20me1 |
| SETDB1 | ESET; KMT1E | 9869 | 1q21.3 | H3K9me1/2/3 |
| SETDB2 | CLL8; KMT1F | 83852 | 13q14.2 | H3K9 |
| SETMAR | METNASE | 6419 | 3p26.1 | H3K36 |
| SMYD1 | KMT3D; ZMYND18 | 150572 | 2p11.2 | H3K4 |
| SMYD2 | KMT3C; ZMYND14 | 56950 | 1q32.3 | H3K4; H3K36me2 |
| SMYD3 | KMT3E; ZMYND1; | 64754 | 1q44 | H3K4me2/3 |
| SMYD4 | ZMYND21 | 114826 | 17p13.3 | |
| SMYD5 | RRG1; ZMYND23 | 10322 | 2p13.2 | |
| SUV39H1 | KMT1A | 6839 | Xp11.23 | H3K9me2/3 |
| SUV39H2 | KMT1B | 79723 | 10p13 | H3K9me2/3 |
| SUV420H1 | KMT5B; CGI-85 | 51111 | 11q13.2 | H4K20me2/3 |
| SUV420H2 | KMT5C | 84787 | 19q13.42 | H4K20me2/3 |
| WHSC1 | NSD2; MMSET | 7468 | 4p16.3 | H3K36me1/2 |
| WHSC1L1 | NSD3 | 54904 | 8p11.23 | H3K36me1/2; H3K4 |