Table 1.
Frequency of HMTs copy number alterations and mutations (%).
| Gene | Location | Amp | Gain | Diploid | Hetloss | Homdel | Mutation |
|---|---|---|---|---|---|---|---|
| SETDB2 | 13q14.2 | 0.00 | 0.81 | 54.88 | 27.64 | 16.67 | 0.24 |
| PRDM1 | 6q21 | 0.00 | 0.41 | 67.07 | 18.70 | 13.82 | 0.00 |
| PRDM13 | 6q16.2 | 0.00 | 1.22 | 66.06 | 19.11 | 13.62 | 0.00 |
| PRDM7 | 16q24.3 | 0.20 | 1.02 | 60.57 | 29.88 | 8.33 | 0.47 |
| WHSC1L1 | 8p11.23 | 2.64 | 11.38 | 52.44 | 27.44 | 6.10 | 0.71 |
| PRDM5 | 4q27 | 0.00 | 2.85 | 87.60 | 6.30 | 3.25 | 0.24 |
| EZH1 | 17q21.2 | 0.00 | 1.02 | 86.18 | 10.16 | 2.64 | 0.24 |
| SETD5 | 3p25.3 | 0.20 | 6.91 | 85.77 | 4.47 | 2.64 | 0.24 |
| SETD6 | 16q21 | 0.20 | 1.22 | 73.98 | 21.95 | 2.64 | 0.00 |
| PRDM11 | 11p11.2 | 0.20 | 4.47 | 88.82 | 4.27 | 2.24 | 0.00 |
| PRDM6 | 5q23.2 | 0.20 | 2.64 | 87.20 | 8.13 | 1.83 | 0.00 |
| KMT2A | 11q23.3 | 0.41 | 5.89 | 85.77 | 6.30 | 1.63 | 1.18 |
| PRDM15 | 21q22.3 | 0.00 | 4.67 | 87.40 | 6.50 | 1.42 | 0.24 |
| SETD1B | 12q24.31 | 0.81 | 4.88 | 87.20 | 5.69 | 1.42 | 0.00 |
| SETD2 | 3p21.31 | 0.00 | 7.11 | 87.80 | 3.66 | 1.42 | 0.94 |
| SETMAR | 3p26.1 | 0.20 | 7.32 | 86.79 | 4.27 | 1.42 | 0.00 |
| SMYD2 | 1q32.3 | 0.00 | 6.30 | 88.41 | 3.86 | 1.42 | 0.24 |
| KMT2C | 7q36.1 | 0.41 | 18.70 | 75.41 | 4.27 | 1.22 | 5.41 |
| SETD3 | 14q32.2 | 0.41 | 2.64 | 89.02 | 6.71 | 1.22 | 0.00 |
| PRDM10 | 11q24.3 | 0.81 | 6.10 | 87.60 | 4.47 | 1.02 | 0.24 |
| SMYD4 | 17p13.3 | 0.00 | 1.42 | 80.08 | 17.48 | 1.02 | 0.00 |
| PRDM2 | 1p36.21 | 0.20 | 0.61 | 89.23 | 9.15 | 0.81 | 0.47 |
| SETD8 | 12q24.31 | 0.61 | 4.27 | 87.40 | 6.91 | 0.81 | 0.00 |
| SMYD5 | 2p13.2 | 0.41 | 2.64 | 90.24 | 5.89 | 0.81 | 0.00 |
| DOT1L | 19p13.3 | 0.20 | 1.22 | 90.24 | 7.72 | 0.61 | 0.71 |
| PRDM9 | 5p14.2 | 0.61 | 6.30 | 89.43 | 3.05 | 0.61 | 0.71 |
| SETD1A | 16p11.2 | 0.41 | 6.10 | 86.79 | 6.10 | 0.61 | 0.47 |
| SMYD3 | 1q44 | 0.41 | 5.89 | 90.04 | 3.05 | 0.61 | 0.00 |
| SUV39H2 | 10p13 | 0.41 | 3.46 | 86.59 | 8.94 | 0.61 | 0.00 |
| SUV420H1 | 11q13.2 | 2.44 | 7.32 | 89.02 | 0.61 | 0.61 | 0.24 |
| WHSC1 | 4p16.3 | 1.02 | 2.85 | 89.43 | 6.10 | 0.61 | 0.24 |
| ASH1L | 1q22 | 1.42 | 6.10 | 90.04 | 2.03 | 0.41 | 1.88 |
| EHMT2 | 6p21.31 | 0.20 | 3.66 | 91.46 | 4.27 | 0.41 | 0.24 |
| EZH2 | 7q36.1 | 0.41 | 18.70 | 79.07 | 1.42 | 0.41 | 0.24 |
| KMT2B | 19q13.12 | 0.41 | 2.03 | 92.89 | 4.27 | 0.41 | 0.47 |
| KMT2E | 7q22.3 | 0.81 | 18.70 | 78.25 | 1.83 | 0.41 | 0.94 |
| PRDM16 | 1p36.32 | 0.41 | 1.63 | 89.43 | 8.13 | 0.41 | 0.24 |
| PRDM8 | 4q21.21 | 0.41 | 2.64 | 92.89 | 3.66 | 0.41 | 0.71 |
| SETD4 | 21q22.12 | 0.00 | 4.67 | 89.23 | 5.69 | 0.41 | 0.00 |
| SETD7 | 4q31.1 | 0.00 | 3.25 | 91.26 | 5.08 | 0.41 | 0.00 |
| SMYD1 | 2p11.2 | 0.41 | 2.24 | 91.46 | 5.49 | 0.41 | 0.00 |
| PRDM12 | 9q34.12 | 1.22 | 10.57 | 85.37 | 2.64 | 0.20 | 0.47 |
| PRDM4 | 12q23.3 | 1.02 | 5.28 | 88.82 | 4.67 | 0.20 | 0.00 |
| EHMT1 | 9q34.3 | 1.42 | 10.57 | 85.37 | 2.64 | 0.00 | 0.00 |
| KMT2D | 12q13.12 | 0.20 | 3.25 | 91.87 | 4.67 | 0.00 | 4.94 |
| MECOM | 3q26.2 | 3.66 | 13.62 | 80.69 | 2.03 | 0.00 | 1.18 |
| NSD1 | 5q35.2 | 0.81 | 4.27 | 91.67 | 3.25 | 0.00 | 0.47 |
| PRDM14 | 8q13.3 | 6.10 | 24.80 | 68.29 | 0.81 | 0.00 | 0.47 |
| SETDB1 | 1q21.3 | 1.42 | 6.71 | 91.26 | 0.61 | 0.00 | 0.47 |
| SUV39H1 | Xp11.23 | 1.02 | 2.64 | 90.85 | 5.49 | 0.00 | 0.00 |
| SUV420H2 | 19q13.42 | 0.41 | 4.07 | 91.46 | 4.07 | 0.00 | 0.24 |
Amp – high-level amplification; Gain – low-level gain; Hetless – heterozygous deletion; Homdel – homozygous deletion. Genes were ranked based on the frequency of Homdel.