Supplementary Table 6.
Summary for differential promoter methylation HMTs in paired normal and tumor tissues.
| Gene | Differential methylation analysis of 46 HMTs | Paired T-test | |||||
|---|---|---|---|---|---|---|---|
| logFC | AveExpr | t | P.value | adj.P.Val | B | ||
| PRDM14 | −0.201 | 0.320 | −11.345 | 1.30E-19 | 6.09E-18 | 33.276 | 1.75E-17 |
| NSD1 | −0.142 | 0.421 | −9.479 | 1.49E-15 | 3.50E-14 | 23.928 | 2.44E-13 |
| PRDM8 | −0.146 | 0.432 | −8.138 | 1.20E-12 | 1.89E-11 | 17.253 | 6.68E-12 |
| EZH1 | −0.024 | 0.103 | −7.529 | 2.41E-11 | 2.83E-10 | 14.277 | 1.61E-10 |
| PRDM13 | −0.121 | 0.306 | −7.276 | 8.19E-11 | 7.70E-10 | 13.062 | 6.16E-12 |
| PRDM6 | −0.065 | 0.158 | −6.626 | 1.81E-09 | 1.42E-08 | 9.998 | 6.49E-10 |
| PRDM12 | −0.047 | 0.119 | −6.586 | 2.18E-09 | 1.47E-08 | 9.813 | 3.76E-10 |
| SETD3 | 0.061 | 0.604 | 6.222 | 1.18E-08 | 6.93E-08 | 8.149 | 3.26E-08 |
| PRDM5 | −0.093 | 0.117 | −5.224 | 9.70E-07 | 5.07E-06 | 3.821 | 2.09E-06 |
| KMT2B | 0.057 | 0.551 | 4.548 | 1.54E-05 | 7.22E-05 | 1.136 | 5.32E-06 |
| PRDM15 | −0.012 | 0.157 | −4.393 | 2.81E-05 | 1.20E-04 | 0.554 | 2.38E-05 |
| SETD5 | 0.037 | 0.474 | 3.924 | 1.61E-04 | 6.31E-04 | −1.122 | 6.03E-05 |
| PRDM7 | 0.041 | 0.537 | 3.845 | 2.13E-04 | 7.71E-04 | −1.391 | 1.73E-04 |
| WHSC1 | 0.023 | 0.463 | 3.619 | 4.67E-04 | 1.57E-03 | −2.136 | 2.21E-04 |
| SETDB1 | 0.014 | 0.140 | 3.088 | 2.61E-03 | 8.19E-03 | −3.749 | 1.03E-04 |
| EHMT2 | 0.004 | 0.097 | 2.887 | 4.78E-03 | 1.40E-02 | −4.307 | 3.23E-04 |
| MECOM | −0.016 | 0.151 | −2.837 | 5.52E-03 | 1.53E-02 | −4.439 | 3.26E-03 |
| KMT2E | −0.031 | 0.417 | −2.721 | 7.69E-03 | 1.72E-02 | −4.741 | 5.31E-03 |
| SETD1A | 0.009 | 0.127 | 2.725 | 7.60E-03 | 1.72E-02 | −4.731 | 6.35E-03 |
| SMYD1 | 0.050 | 0.805 | 2.747 | 7.14E-03 | 1.72E-02 | −4.674 | 5.86E-03 |
| PRDM9 | 0.071 | 0.586 | 2.735 | 7.39E-03 | 1.72E-02 | −4.705 | 9.94E-04 |
| SUV420H1 | −0.008 | 0.225 | −2.700 | 8.16E-03 | 1.74E-02 | −4.795 | 2.43E-03 |
| PRDM2 | 0.007 | 0.431 | 2.583 | 1.13E-02 | 2.30E-02 | −5.087 | 3.74E-03 |
| PRDM11 | 0.019 | 0.845 | 2.497 | 1.42E-02 | 2.77E-02 | −5.293 | 9.22E-03 |
| PRDM4 | −0.004 | 0.062 | −2.420 | 1.73E-02 | 3.26E-02 | −5.473 | 1.23E-02 |
| PRDM10 | 0.025 | 0.564 | 2.390 | 1.87E-02 | 3.38E-02 | −5.542 | 2.59E-02 |
| DOT1L | 0.002 | 0.036 | 2.290 | 2.42E-02 | 4.20E-02 | −5.766 | 9.03E-03 |
| SMYD5 | 0.008 | 0.230 | 1.982 | 5.02E-02 | 8.43E-02 | −6.401 | 3.76E-02 |
| SETD7 | 0.003 | 0.057 | 1.902 | 6.00E-02 | 9.73E-02 | −6.551 | 2.41E-02 |
| SETMAR | −0.005 | 0.173 | −1.523 | 1.31E-01 | 2.05E-01 | −7.188 | 8.77E-02 |
| SETD4 | 0.001 | 0.032 | 1.425 | 1.57E-01 | 2.39E-01 | −7.331 | 1.30E-01 |
| KMT2D | 0.003 | 0.079 | 1.318 | 1.91E-01 | 2.71E-01 | −7.476 | 5.25E-02 |
| SETDB2 | 0.005 | 0.905 | 1.335 | 1.85E-01 | 2.71E-01 | −7.454 | 1.62E-01 |
| WHSC1L1 | −0.004 | 0.151 | −1.244 | 2.17E-01 | 2.99E-01 | −7.571 | 2.39E-01 |
| SUV39H2 | 0.001 | 0.041 | 1.191 | 2.36E-01 | 3.09E-01 | −7.634 | 2.32E-01 |
| AR | 0.005 | 0.316 | 1.191 | 2.36E-01 | 3.09E-01 | −7.634 | 1.74E-01 |
| PRDM1 | −0.014 | 0.148 | −1.147 | 2.54E-01 | 3.23E-01 | −7.686 | 2.81E-01 |
| SETD2 | 0.001 | 0.036 | 0.996 | 3.22E-01 | 3.98E-01 | −7.847 | 2.55E-01 |
| ASH1L | 0.003 | 0.473 | 0.978 | 3.31E-01 | 3.98E-01 | −7.865 | 2.85E-01 |
| SUV420H2 | −0.001 | 0.025 | −0.908 | 3.66E-01 | 4.30E-01 | −7.931 | 3.20E-01 |
| SMYD2 | −0.002 | 0.062 | −0.828 | 4.10E-01 | 4.70E-01 | −8.001 | 3.54E-01 |
| SMYD3 | −0.002 | 0.413 | −0.685 | 4.95E-01 | 5.29E-01 | −8.109 | 4.27E-01 |
| EZH2 | −0.001 | 0.295 | −0.703 | 4.84E-01 | 5.29E-01 | −8.097 | 3.90E-01 |
| SETD6 | −0.001 | 0.039 | −0.717 | 4.75E-01 | 5.29E-01 | −8.086 | 3.54E-01 |
| SETD8 | 0.000 | 0.030 | −0.373 | 7.10E-01 | 7.42E-01 | −8.275 | 6.77E-01 |
| KMT2A | 0.000 | 0.030 | 0.107 | 9.15E-01 | 9.35E-01 | −8.340 | 8.71E-01 |
| SUV39H1 | 0.000 | 0.115 | 0.057 | 9.55E-01 | 9.55E-01 | −8.344 | 9.52E-01 |