Supplementary Table 8B.

Summary of multivariate analysis of RFS for deletion of 10 HMTs in prostate cancer.

Multivariate		Age	Pathology T	Gleason score	AR expression	DOT1L deletion
Coefficient		−0.003	0.742	0.971	0.304	0.441
Hazard ratio		0.997	2.101	2.64	1.356	1.554
95%CI	Lower	0.962	1.118	1.585	0.847	0.815
	Higher	1.033	3.945	4.397	2.17	2.963
p-Value		0.8719	0.021	0.0002	0.2053	0.1802
Multivariate		Age	Pathology T	Gleason score	AR expression	EHMT2 deletion
Coefficient		0.004	0.775	0.951	0.176	0.992
Hazard ratio		1.004	2.17	2.588	1.193	2.695
95%CI	Lower	0.968	1.156	1.548	0.743	1.135
	Higher	1.042	4.074	4.327	1.916	6.398
p-Value		0.81	0.016	0.0003	0.4662	0.0246
Multivariate		Age	Pathology T	Gleason score	AR expression	PRDM7 deletion
Coefficient		0.003	0.796	0.947	0.196	0.333
Hazard ratio		1.003	2.217	2.577	1.216	1.395
95%CI	Lower	0.969	1.19	1.563	0.773	0.881
	Higher	1.039	4.133	4.25	1.914	2.208
p-Value		0.8706	0.0122	0.0002	0.397	0.1559
Multivariate		Age	Pathology T	Gleason score	AR expression	SETD4 deletion
Coefficient		−0.006	0.733	0.991	0.177	1.097
Hazard ratio		0.994	2.081	2.694	1.194	2.996
95%CI	Lower	0.959	1.107	1.598	0.738	1.336
	Higher	1.031	3.91	4.545	1.932	6.716
p-Value		0.7515	0.0229	0.0002	0.4706	0.0077
Multivariate		Age	Pathology T	Gleason score	AR expression	SETD6 deletion
Coefficient		0	0.762	0.911	0.24	0.491
Hazard ratio		1	2.143	2.486	1.271	1.634
95%CI	Lower	0.966	1.146	1.486	0.805	1.018
	Higher	1.035	4.006	4.159	2.008	2.622
p-Value		0.9999	0.017	0.0005	0.3036	0.042
Multivariate		Age	Pathology T	Gleason score	AR expression	SETDB2 deletion
Coefficient		−0.007	0.835	0.928	0.125	0.322
Hazard ratio		0.993	2.305	2.531	1.133	1.38
95%CI	Lower	0.96	1.237	1.529	0.721	0.868
	Higher	1.028	4.298	4.189	1.782	2.195
p-Value		0.6953	0.0086	0.0003	0.5873	0.1739
Multivariate		Age	Pathology T	Gleason score	AR expression	SMYD1 deletion
Coefficient		0	0.755	0.96	0.309	0.998
Hazard ratio		1	2.128	2.612	1.362	2.714
95%CI	Lower	0.964	1.135	1.558	0.848	1.329
	Higher	1.038	3.99	4.378	2.189	5.543
p-Value		0.9902	0.0185	0.0003	0.2012	0.0061
Multivariate		Age	Pathology T	Gleason score	AR expression	SUV39H2 deletion
Coefficient		−0.013	0.774	0.976	0.187	0.755
Hazard ratio		0.987	2.169	2.655	1.205	2.129
95%CI	Lower	0.953	1.15	1.588	0.761	1.199
	Higher	1.022	4.092	4.437	1.909	3.778
p-Value		0.4618	0.0168	0.0002	0.4265	0.0099
Multivariate		Age	Pathology T	Gleason score	AR expression	SUV420H2 deletion
Coefficient		0	0.77	0.89	0.289	0.553
Hazard ratio		1	2.16	2.435	1.335	1.738
95%CI	Lower	0.964	1.147	1.443	0.831	0.808
	Higher	1.037	4.071	4.108	2.144	3.736
p-Value		0.9946	0.0172	0.0009	0.232	0.1572
Multivariate		Age	Pathology T	Gleason score	AR expression	WHSC1L1 deletion
Coefficient		−0.001	0.681	1.184	0.121	0.677
Hazard ratio		0.999	1.976	3.267	1.129	1.968
95%CI	Lower	0.959	1.028	1.867	0.671	1.173
	Higher	1.04	3.8	5.716	1.899	3.303
p-Value		0.9534	0.0411	0	0.6489	0.0103