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. 2019 Jan 7;25:193–239. doi: 10.12659/MSM.912294

Supplementary Table 8D.

Summary of multivariate analysis of RFS for higher mRNA level of 16 HMTs in prostate cancer.

Multivariate Age Pathology T Gleason score AR expression DOT1L high_exp
Coefficient −0.004 0.854 0.916 0.163 0.254
Hazard ratio 0.996 2.35 2.5 1.177 1.289
95%CI Lower 0.962 1.26 1.504 0.747 0.802
Higher 1.032 4.382 4.157 1.855 2.071
p-Value 0.8373 0.0072 0.0004 0.4813 0.2941
Multivariate Age Pathology T Gleason score AR expression EZH2 high_exp
Coefficient −0.006 0.858 0.731 0.185 0.736
Hazard ratio 0.994 2.357 2.076 1.203 2.088
95%CI Lower 0.961 1.263 1.23 0.768 1.23
Higher 1.028 4.4 3.506 1.887 3.544
p-Value 0.7334 0.0071 0.0063 0.4195 0.0064
Multivariate Age Pathology T Gleason score AR expression KMT2B high_exp
Coefficient −0.004 0.877 0.923 −0.026 0.387
Hazard ratio 0.996 2.403 2.516 0.975 1.472
95%CI Lower 0.962 1.288 1.526 0.563 0.839
Higher 1.031 4.484 4.149 1.688 2.584
p-Value 0.8266 0.0059 0.0003 0.9268 0.1781
Multivariate Age Pathology T Gleason score AR expression KMT2D high_exp
Coefficient −0.004 0.857 0.906 0.087 0.333
Hazard ratio 0.996 2.357 2.474 1.091 1.396
95%CI Lower 0.962 1.264 1.492 0.677 0.851
Higher 1.031 4.393 4.102 1.758 2.289
p-Value 0.8135 0.007 0.0004 0.721 0.1865
Multivariate Age Pathology T Gleason score AR expression PRDM10 high_exp
Coefficient −0.003 0.829 0.94 0.054 0.266
Hazard ratio 0.997 2.291 2.56 1.055 1.304
95%CI Lower 0.963 1.23 1.551 0.617 0.755
Higher 1.033 4.267 4.227 1.804 2.255
p-Value 0.878 0.009 0.0002 0.8443 0.3412
Multivariate Age Pathology T Gleason score AR expression PRDM12 high_exp
Coefficient −0.005 0.841 0.923 0.231 0.224
Hazard ratio 0.995 2.319 2.517 1.26 1.251
95%CI Lower 0.962 1.245 1.512 0.799 0.773
Higher 1.03 4.322 4.188 1.988 2.024
p-Value 0.7926 0.0081 0.0004 0.3195 0.362
Multivariate Age Pathology T Gleason score AR expression PRDM15 high_exp
Coefficient −0.003 0.856 0.909 0.153 0.448
Hazard ratio 0.997 2.354 2.483 1.165 1.566
95%CI Lower 0.964 1.264 1.507 0.742 0.981
Higher 1.033 4.383 4.092 1.83 2.5
p-Value 0.8865 0.007 0.0004 0.5069 0.0604
Multivariate Age Pathology T Gleason score AR expression PRDM16 high_exp
Coefficient −0.006 0.898 0.948 0.175 −0.514
Hazard ratio 0.994 2.454 2.581 1.191 0.598
95%CI Lower 0.96 1.315 1.571 0.759 0.377
Higher 1.029 4.579 4.24 1.87 0.949
p-Value 0.747 0.0048 0.0002 0.4462 0.0293
Multivariate Age Pathology T Gleason score AR expression PRDM6 high_exp
Coefficient −0.003 0.851 0.897 0.208 −0.506
Hazard ratio 0.997 2.343 2.452 1.231 0.603
95%CI Lower 0.963 1.259 1.486 0.785 0.377
Higher 1.032 4.36 4.046 1.931 0.964
p-Value 0.8603 0.0072 0.0004 0.366 0.0345
Multivariate Age Pathology T Gleason score AR expression PRDM8 high_exp
Coefficient −0.005 0.857 0.916 0.208 −0.284
Hazard ratio 0.995 2.356 2.499 1.231 0.753
95%CI Lower 0.962 1.261 1.504 0.785 0.47
Higher 1.03 4.401 4.155 1.93 1.206
p-Value 0.7952 0.0072 0.0004 0.3658 0.2375
Multivariate Age Pathology T Gleason score AR expression SETD1B high_exp
Coefficient −0.008 0.861 0.903 0.059 0.453
Hazard ratio 0.992 2.365 2.468 1.06 1.573
95%CI Lower 0.958 1.271 1.496 0.661 0.957
Higher 1.028 4.401 4.071 1.701 2.584
p-Value 0.6715 0.0066 0.0004 0.8076 0.0738
Multivariate Age Pathology T Gleason score AR expression SETD5 high_exp
Coefficient −0.005 0.784 0.903 0.033 0.584
Hazard ratio 0.995 2.191 2.466 1.033 1.794
95%CI Lower 0.961 1.176 1.496 0.646 1.1
Higher 1.031 4.082 4.067 1.651 2.926
p-Value 0.7935 0.0135 0.0004 0.8915 0.0193
Multivariate Age Pathology T Gleason score AR expression SMYD1 high_exp
Coefficient −0.009 0.862 1.002 0.191 −0.819
Hazard ratio 0.991 2.369 2.723 1.21 0.441
95%CI Lower 0.957 1.269 1.662 0.772 0.232
Higher 1.027 4.423 4.461 1.896 0.838
p-Value 0.623 0.0068 0.0001 0.405 0.0124
Multivariate Age Pathology T Gleason score AR expression SUV39H1 high_exp
Coefficient −0.007 0.86 0.925 0.22 0.329
Hazard ratio 0.993 2.363 2.521 1.246 1.39
95%CI Lower 0.958 1.267 1.525 0.792 0.866
Higher 1.028 4.407 4.167 1.958 2.23
p-Value 0.6758 0.0068 0.0003 0.3412 0.1728
Multivariate Age Pathology T Gleason score AR expression SUV420H2 high_exp
Coefficient −0.009 0.852 0.847 0.382 0.586
Hazard ratio 0.991 2.344 2.334 1.465 1.796
95%CI Lower 0.957 1.257 1.402 0.909 1.087
Higher 1.027 4.37 3.884 2.361 2.966
p-Value 0.6247 0.0073 0.0011 0.1165 0.0222
Multivariate Age Pathology T Gleason score AR expression WHSC1 high_exp
Coefficient −0.005 0.815 0.831 0.146 0.429
Hazard ratio 0.995 2.259 2.297 1.157 1.535
95%CI Lower 0.961 1.21 1.357 0.735 0.913
Higher 1.03 4.217 3.888 1.821 2.581
p-Value 0.7789 0.0105 0.002 0.5276 0.1057