Table 4.

Risk of adverse maternal and neonatal outcomes in normotensive and new stage 1 hypertensive women receiving placebo or low-dose aspirin

	PLACEBO		ASPIRIN
Outcome	Normo- tension N=1384	Stage 1 Hypertension N=98	Normotension N=1399	Stage 1 Hypertension N=66
Preeclampsia	1.00 (ref)	RR 2.82 (1.69-4.73) aRR 2.06 (1.14-3.73)	RR 0.80 (0.58-1.12) aRR 0.80 (0.57-1.11)	RR 1.40 (0.58-3.34) aRR 1.01 (0.43-2.36)
Mild Preeclampsia	1.00 (ref)	RR 3.18 (1.59-6.36) aRR 2.17 (0.95-5.00)	RR 0.82 (0.52-1.29) aRR 0.81 (0.51-1.28)	RR 2.10 (0.77-5.69) aRR 1.44 (0.54-3.86)
Severe Preeclampsia	1.00 (ref)	RR 2.42 (1.04-5.62) aRR 1.81 (0.74-4.38)	RR 0.79 (0.48-1.29) aRR 0.78 (0.48-1.27)	RR 0.60 (0.08-4.31) aRR 0.46 (0.06-3.30)
Gestational diabetes	1.00 (ref)	RR 2.49 (1.07-5.78) aRR 0.84 (0.29-2.42)	RR 1.46 (0.95-2.24) aRR 1.50 (0.97-2.31)	RR 1.23 (0.30-5.02) aRR 0.73 (0.16-3.27)
Small for gestational age	1.00 (ref)	RR 1.83 (0.98-3.43) aRR 2.16 (1.12-4.16)	RR 0.84 (0.61-1.15) aRR 0.86 (0.62-1.19)	RR 1.36 (0.57-3.25) aRR 1.60 (0.68-3.78)
Indicated PTD	1.00 (ref)	RR 3.79 (1.28-11.20) aRR 3.98 (1.36-11.70)	RR 1.78 (0.95-3.33) aRR 1.75 (0.92-3.34)	NA
Spontaneous PTD	1.00 (ref)	RR 0.66 (0.27-1.57) aRR 0.78 (0.32-1.90)	RR 0.96 (0.74-1.24) aRR 0.95 (0.73-1.24)	RR 0.98 (0.41-2.32) aRR 1.08 (0.46-2.52)
NICU admission	1.00 (ref)	RR 1.41 (0.81-2.47) aRR 0.97 (0.53-1.78)	RR 0.92 (0.71-1.17) aRR 0.93 (0.73-1.19)	RR 1.40 (0.71-2.73) aRR 1.31 (0.64-2.69)

Data are risk ratios (95% confidence interval). aRR: risk ratios with adjustment for pre-pregnancy BMI, race, and maternal age; PTD= preterm delivery, NICU= neonatal intensive care unit