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. Author manuscript; available in PMC: 2019 May 21.
Published in final edited form as: Nature. 2018 Nov 21;563(7733):714–718. doi: 10.1038/s41586-018-0735-5

Figure 1. Transcriptional programs initiated during efferocytosis.

Figure 1.

(a) Phagocytes regulate distinct transcriptional modules during efferocytosis. LR73 hamster fibroblasts were incubated with apoptotic human Jurkat cells and RNAseq performed. Focusing on hamster-derived mRNA, the 1450 total genes modulated were categorized per primary function and sequence similarity. Significance was assigned if multiple-comparisons and adjusted p value per DESeq2 algorithm was < 0.1. Data are from four independent experimental replicates. (b) Differentially regulated SLC genes are represented using network analysis to determine family clusters (shaded areas) and connectedness between individual SLCs.