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. Author manuscript; available in PMC: 2019 May 21.
Published in final edited form as: Nature. 2018 Nov 21;563(7733):714–718. doi: 10.1038/s41586-018-0735-5

Extended Data Figure 2. SLC modified during efferocytosis.

Extended Data Figure 2.

(a) Solute carrier (SLC) genes are differentially regulated during efferocytosis. (left) Plotting of the 165 SLC genes detected by RNAseq of efferoytic LR73 cells highlighting the 19 significantly upregulated (red) and 14 downregulated (blue) SLC genes that were altered during efferocytosis. The 132 SLC genes that were not altered are located on the midline (black). The current genetic classifications of these 33 SLC genes altered during engulfment are shown (right).

(b) Efferocytosis associated SLCs and their properties. Current genetic classification/functional linkages of the 33 SLCs modulated during apoptotic cell engulfment. Shown are the significantly upregulated and downregulated SLCs and the substrates they are known to transport grouped by predicted general function, as well as the known monogenic diseases and SNP/disease phenotype to which the specific SLCs have been linked.