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. 2018 Dec 25;9(101):37564–37580. doi: 10.18632/oncotarget.26500

Figure 5. Effects of TLR-4 on tumor growth.

Figure 5

Effect of TLR-4 absence on mean tumor weight (A) and tumor burden (B) in nude mice grafted with U-87 MG cells. During the 28-days observation period, tumor growth was significantly reduced in TLR-4 KO mice respect to Control WT mice (C). The histological tumor evaluation highlighted necrosis and associated neutrophilic inflammation more present in tumors from Control WT mice respect to TLR-4 KO tumor sections (D and E). Each data are expressed as mean ± SEM. T-test followed by unpaired test and Two-way ANOVA followed by Bonferroni post test. ***p < 0.001 vs Ctr.