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KSHV-infected endothelial lineage cells in KS express the oncogenic viral genes LANA and vGPCR, which activates nuclear YAP and TAZ. Activating fusions of YAP or TAZ are present in some epithelioid hemangioendotheliomas (image of JM Gardner). The tumor suppressor DLC1 protein is abnormally low in angiosarcomas compared to the normal endothelium; angiosarcomas contain active YAP/TAZ.
