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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Bioorg Med Chem. 2018 Oct 24;26(22):5766–5779. doi: 10.1016/j.bmc.2018.10.009

Scheme 1. One-Step Synthesis of α, α-Dichloro-Retinal Analog.

Scheme 1.

Retinoic acid ethyl ester was reacted with dichloromethyllithium generated in situ from dichloromethane (DCM) and lithium diisopropylamide (LDA) in ethyl ether (Et2O) to generate α,α-dichloro-all-trans-retinone (DAR). 4 – 10% of DAR was produced in each reaction.