. 2019 Jan 9;11:561–571. doi: 10.2147/CMAR.S180261

Table 2.

Studies reporting posttreatment effect of celecoxib on incidence of recurrent colorectal adenomas after 2 years of off-treatment

Reference, year	Study name	Design	Subjects	Treatment duration (years)	Follow-up colonoscopy	Duration of off-treatment (years)	Study group (N, originally randomized)	Subjects completed follow-up colonoscopy, n	Efficacy outcomes^a (n/N)
Reference, year	Study name	Design	Subjects	Treatment duration (years)	Follow-up colonoscopy	Duration of off-treatment (years)	Study group (N, originally randomized)	Subjects completed follow-up colonoscopy, n	Any adenomas	Advanced adenomas
Arber et al, 2011³⁰	5-year analysis of PreSAP	Follow-up of double-blind, placebo-controlled RCT; multicenter; parallel two-arm	Mean age 60; 66% males	3	5	2	Celecoxib 400 mg/day (n=933)	508	186/508	NA
Arber et al, 2011³⁰	5-year analysis of PreSAP		Mean age 60; 66% males	3	5	2	Placebo (n=628)	347	86/347	NA
Bertagnolli et al, 2009³¹	5-year analysis of APC	Follow-up of double-blind, placebo-controlled RCT; multicenter; parallel three-arm	Median age 59; 71% males	3	5	2	Celecoxib 400 mg/day (n=685)	207	83/207	13/207
							Celecoxib 800 mg/day (n=671)	218	90/218	22/219
							Placebo (n=679)	214	79/214	11/214
Thompson et al, 2016⁴¹	Sel/Cel	Follow-up of double-blind, placebo-controlled RCT; multicenter; 2×2 factorial	Median age 59; 71% males	1^b	5.5^c	~4	Celecoxib 400 mg/day (n=414)	329	124/329	28/319^d
Thompson et al, 2016⁴¹	Sel/Cel		Median age 59; 71% males	1^b	5.5^c	~4	Placebo (n=410)	336	135/336	32/332^d

Notes:

Arber et al, 2011³⁰ – efficacy outcomes from 855 subjects who had colonoscopy at year 5, even if they had one or more new adenomas detected at any time after baseline; Bertagnolli et al, 2009³¹ – efficacy outcomes from 639 subjects in the extension study with any adenoma detected at the year 5 colonoscopy; Thompson et al, 2016⁴¹ – efficacy outcomes from 447 subjects with a follow-up colonoscopy within 3.5 years of qualifying colonoscopy.

Study reported that the median time for taking placebo and intervention, respectively, was 13.6 and 14.2 months.

Reported efficacy outcomes from follow-up colonoscopy within 5.5 years.

Number of advanced adenomas uncertain for some participants.

Abbreviations: APC, Adenoma Prevention with Celecoxib trial; PreSAP, Prevention of Colorectal Sporadic Adenomatous Polyps Study; RCTs, randomized controlled trials; Sel/Cel, Selenium and Celecoxib (Sel/Cel) Trial; NA, not available.