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. 2019 Jan 10;11:637–649. doi: 10.2147/CMAR.S185117

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© 2019 Ma et al. This work is published and licensed by Dove Medical Press Limited

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miR-4458 inhibited cell proliferation in NSCLC cells.

Notes: (A) Relative expression level of miR-4458 in four NSCLC cell lines (A549, H1299, HCC827, and PC9) and one normal lung cell (HBE). (B) The expression of miR-4458 after 48 hours of transfection with NC, mimics, inhibitor NC, and inhibitor by qRT-PCR. (C) The rate of cell growth was measured by Edu assay. (D) CCK-8 assay confirmed that miR-4458 inhibited cell proliferation in NSCLC cells. (E) The ability of colony formation was reduced with the overexpression of miR-4458 and enhanced with knockdown of miR-4458. *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: CCK-8, cell-counting kit-8; Edu, 5-ethynyl-2′-deoxyuridine; miR-4458, microRNA-4458; NC, negative control; NSCLC, non-small-cell lung cancer.