Figure 2.

Knockdown of SNHG6 inhibits CRC cell proliferation and tumor growth.

Notes: (A) The relative expression level of SNHG6 in HCT116 and SW480 cells transfected with sh-NC, shRNA1 and shRNA2. ***P<0.001. (B) Cell proliferation as detected by MTT assay in HCT116 and SW480 cells. *P<0.05. (C) Cell proliferation as detected by colony formation assay in HCT116 and SW480 cells. **P<0.01 and ***P<0.001. (D) Representative images of tumor nodes (n=4). (E) The tumor volumes were calculated every week after injection. **P<0.01. (F) The tumor weights in each group. **P<0.01 and ***P<0.001. (G) Representative images of immunochemical staining for Ki67 in xenograft tumors. Scale bars =50 µm. ***P<0.001.

Abbreviation: CRC, colorectal cancer.