Table 4.

Table of identified variants classified as likely pathogenic/pathogenic according to the ClinVar database

Patient	Gene	Nucleotide	Protein	ClinVar classification	Sex/age primary	Personal history (age at diagnosis)	Family history
With SMN
OL0138	CHEK2	c.349A>G	p.Arg117Gly	Class 4–5	Female/70	Breast (71)	0
Without SMN
OL0130	RAD51D	c.345+2T>G	–	Class 4	Male/62	0	Mother – gastric
OL0132	MLH1	c.390C>G	p.Tyr130Ter	Class 5	Female/52	0	Father – colon, father’s mother – brain
	ATM	c.3849delA	p.Leu1283fs	Class 5
PCI77	CHEK2	c.1100delC	p.Thr367fs	Class 5	Male/55	0	0

Note: All variants are heterozygous.

Abbreviation: SMN, subsequent malignant neoplasm after pancreatic ductal adenocarcinoma (PDAC).