Table 2. Hazard ratio of the occurrence of CKD on univariate Cox regression analysis.
| Hazard ratio | Univariate 95% confidence interval |
P value | |
|---|---|---|---|
| Presence of LN | 0.33 | 0.12–0.90 | 0.029 |
| Age | 0.98 | 0.95–1.01 | 0.34 |
| Hemoglobin (g/mL) | 0.86 | 0.71–1.03 | 0.10 |
| Creatinine (mg/dL) | 1.44 | 1.20–1.71 | <0.001 |
| eGFR (mL/min) | 0.98 | 0.97–0.99 | <0.001 |
| Albumin (g/dL) | 0.96 | 0.60–1.54 | 0.86 |
| Low C3 (%) | 1.25 | 0.53–2.95 | 0.62 |
| Low C4 (%) | 1.72 | 0.74–4.00 | 0.21 |
| Positive anti-dsDNA (%) | 1.02 | 0.45–2.31 | 0.97 |
| Proteinuria (mg/dL) | 1.00 | 1.00–1.00 | 0.06 |
| Potent immunosuppressantsa (%) | 0.53 | 0.21–1.36 | 0.19 |
| Prednisolone (mg/day) | 1.05 | 1.01–1.08 | 0.006 |
| Urinary NGAL (ng/mL) | 1.00 | 1.00–1.00 | <0.001 |
| Urinary BKV copies (log)/mL | 0.93 | 0.63–1.38 | 0.71 |
| BKV miR-B1-5p copies (log)/mL | 0.58 | 0.24–1.36 | 0.21 |
| BKV miR-B1-3p copies (log)/mL | 0.80 | 0.50–1.28 | 0.35 |
Anti-dsDNA, anti-double-stranded DNA antibody; BKV, polyomavirus BK; CKD, chronic kidney disease; LN, lupus nephritis; NGAL, neutrophil gelatinase-associated lipocalin
aIncluding mycophenate mofetil, azathioprine, and cyclophosphamide