Table 1. Importance of a Monofluoromethyl Substituent to ER-α Degradation Efficacy.

^aER-α in-cell western in MCF-7 cells (n ≥ 4).

^bMCF-7 proliferation assay (n ≥ 3).

^cEfficacy recorded as percent of efficacy of fulvestrant control.

^dSee ref (7).