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. 2018 Dec 19;10(1):27–33. doi: 10.1021/acsmedchemlett.8b00315

Figure 3.

Figure 3

Subtype selectivity of 6e for KCNQ channels. (A) In the voltage protocol, cells were held at −80 mV and stepped to a series of voltages ranging from −90 to +60 mV in 10 mV increments for a 1500 ms pulse followed by stepping to −120 mV for 500 ms. (B) Histogram showing the effects of 6e on different subtypes of KCNQ with currents measured at −10 and +60 mV. (C) Whole-cell currents of CHO cells transfected individually with KCNQ1 to KCNQ5 were recorded in the absence (left panels) and presence (right panels) of 10 μM 6e.