Figure 2.

Screening results for the Suzuki–Miyaura cross-coupling of 8-haloquinolines 2 and 3 with phenylboronic acid derivatives 4 and 5 at three different temperatures (25, 40, and 85 °C) with four different Pd catalysts in the presence of diazirine-containing spectator 1. Size of circle proportionate to the conversion to desired product 6 as determined by HPLC UV area % (value given inside circle). Color of each circle indicates the mol % diazirine 1 remaining after 3 h. Warmer colors and larger circles represent more favorable reaction outcomes.