Table 2. Physicochemical Properties Determined for the Cyclopeptides.

cyclopeptide	Log D, pH 7.0a	solubility PBS, pH 7.4/pH 1.0 (μM)b	PAMPA (Pe × 10–6 cm/s)c
2	5.8	0.94/1.17	0.6
3	6.0	0.38/3.46	1.0
4	3.7	0.55/0.38	0.2
5	6.3	0.18/0.74	0.3
6	8.0	0.71/5.32	0.2
7	7.7	0.12/0.21	2.0
8	3.1	nd	d
9	3.7	nd	e
10	3.9	436.52/28.33	0.2

^aMeasured (see Supporting Information).

^bNumber of replicates, n = 2.

^cNumber of replicates, n = 3; nd: not determined.

^dCompound was not detected in the acceptor compartment (lower limit of quantitation, LLOQ = 0.02 μM).

^eCompound was not detected in the acceptor compartment (lower limit of quantitation, LLOQ = 0.03 μM).