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Cocrystal structure of 18 bound to STING protein (PDB 6MXE) showing interactions with Thr-263 and Thr-267, with side chain atoms depicted as sticks. As observed with 1, the compound binds in a 2:1 ratio to the STING homodimer and makes the same interactions, with additional van der Waals contact with the side chain phenol of Tyr-167. The homologated carboxylate group maintains a hydrogen bond interaction with Thr-263.
