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. 2018 Dec 4;10(1):111–116. doi: 10.1021/acsmedchemlett.8b00501

Figure 3.

Figure 3

Tissue distribution of lead prodrugs from oral dosing and 24 h pharmacokinetic analysis of Sob-AM2. (A) Distribution from dose (p.o., 9.15 μmol/kg) of sobetirome or lead prodrugs followed by tissue collection 1 h postdose. (B) Serum concentration of Sob-AM2 following single dose (9.15 μmol/kg, i.v.) over 24 h. The elimination phase for Sob-AM2 is highlighted as blue. (C) Brain and serum distribution of sobetirome from a single dose of Sob-AM2 (9.15 μmol/kg, i.v.) over 24 h postdose. (D) Same as that in panel C but dosed by oral gavage (p.o., 9.15 μmol/kg). Data points represent mean ± SEM and n = 3.