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. Author manuscript; available in PMC: 2020 Jan 18.
Published in final edited form as: J Mol Biol. 2018 Nov 22;431(2):178–195. doi: 10.1016/j.jmb.2018.11.019

Figure 10. Model of SSB cooperativity involving bridge and L45 interfaces.

Figure 10.

DNA binding and direct protein interactions connect neighboring SSB tetramers (blue and green). (top) Both the L45 loop and bridge interface contribute to cooperative DNA binding, which can impede RecA access to ssDNA. (bottom) Disruption of the bridge interface disrupts cooperative binding, leading to DNA ‘fraying’ that presents readily-available ssDNA binding sites for RecA or other enzymes.