Table 2 |.
PK parameters of C6CP and PTX in plasma and tumor after administering PM in A2780/CisR tumor bearing mice.
| Parametersa | C6CP, 20 mg/kg | PTX, 20 mg/kg | |||||
|---|---|---|---|---|---|---|---|
| PTX/C6CP PM | C6CP PM | Parameter ratio (PTX/C6CP PM : C6CP PM) |
PTX/C6CP PM | PTXPM | Parameter ratio (PTX/C6CP PM : PTX PM) |
||
| Plasma | t1/2, α (h) | 7.67 | 6.20 | 1.24 | 5.12 | 3.67 | 1.40 |
| Cmax (μg/mL) | 9.40 | 4.73 | 1.99 | 6.51 | 4.62 | 1.41 | |
| AUClast (h*μg/mL) | 34.80 | 30.00 | 1.16 | 18.41 | 9.78 | 1.88 | |
| C1obs (mL/h/kg) | 527.40 | 541.00 | 0.97 | 984.06 | 1434.66 | 0.69 | |
| Vdobs (mL/kg) | 5077.11 | 7963.56 | 0.64 | 10112.89 | 7689.6 | 1.32 | |
| Tumor | AUClast (h*μg/g) | 110.92 | 38.68 | 2.87 | 111.14 | 87.28 | 1.27 |
| Cmax (μg/g) | 9.86 | 4.34 | 2.27 | 8.34 | 5.38 | 1.55 | |
| Tmax (h) | 1 | 1 | 1 | 1 | |||
a
t1/2, α, half-life at the biodistribution phase; Cmax, maximum plasma concentration; AUClast, area under the curve from time 0 to 15 h; Clobs, observed total body clearance; Vdobs, total volume of distribution observed; Tmax, time of maximum concentration.