Table 3 |.
PK parameters of C8CP and PTX in plasma and tumor after administering PM in A2780/CisR tumor bearing mice.
| Parametersa | C8CP, 20 mg/kg | PTX, 20 mg/kg | |||||
|---|---|---|---|---|---|---|---|
| PTX/C8CP PM | C8CP PM | Parameter ratio (PTX/C8CP PM : C8CP PM) |
PTX/C8CP PM | PTXPM | Parameter ratio (PTX/C8CP PM : PTX PM) |
||
| Plasma | t1/2, α (h) | 6.54 | 7.40 | 0.88 | 5.68 | 3.67 | 1.55 |
| Cmax (μg/mL) | 9.50 | 10.92 | 0.87 | 9.39 | 4.62 | 2.03 | |
| AUClast (h*μg/mL) | 37.23 | 45.89 | 0.81 | 21.69 | 9.78 | 2.22 | |
| Clobs (mL/h/kg) | 416.82 | 421.87 | 0.99 | 850.12 | 1434.66 | 0.59 | |
| Vdobs (mL/kg) | 6417.86 | 3066.92 | 2.09 | 8197.41 | 7689.6 | 1.07 | |
| Tumor | AUClast (h*μg/g) | 86.85 | 76.77 | 1.13 | 95.18 | 87.28 | 1.09 |
| Cmax (μg/g) | 9.38 | 9.34 | 1.00 | 7.74 | 5.38 | 1.44 | |
| Tmax (h) | 1 | 1 | 1 | 1 | |||
a
t1/2, α, half-life at the biodistribution phase; Cmax, maximum plasma concentration; AUClast, area under the curve from time 0 to 15 h; Clobs, observed total body clearance; Vdobs, total volume of distribution observed; Tmax, time of maximum concentration.