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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Biomaterials. 2018 Oct 31;192:1–14. doi: 10.1016/j.biomaterials.2018.10.032

Table 4 |.

AUC values calculated for the three-compartmental model presented in Figure 6.

Compartment AUC (arbitrary units)a
Basic scenario A (k13 << k23)
A0 A1 A2 A3 A4
(1) Micellar drug 945.5 1714 2524 4685 2718
(2) Serum-bound drug 1757 1611 1449 1022 1414
(3) Drug in Tumor 4165 4165 4165 4165 4165
Compartment Basic scenario B (k13 = k23)
B0 B1 B2 B3 B4
(1) Micellar drug 712.5 1121 1736 3047 1520
(2) Serum-bound drug 1806 1732 1610 1356 1656
(3) Drug in Tumor 5625 6323 7353 9563 6997
a

Arbitrary numerical value of AUC from 0 to infinity. The parameters used in the calculation are shown in Supplementary Table S5. The PK time profiles are presented in Supplementary Figure S9.