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. Author manuscript; available in PMC: 2020 Jan 18.
Published in final edited form as: J Mol Biol. 2018 Nov 11;431(2):258–272. doi: 10.1016/j.jmb.2018.11.007

Figure 1.

Figure 1.

Characterization of UGT1As. (A) Schematic of domain structure of UGT1A enzymes. (B) Model of full-length UGT1A4 protein. UDP-GlcA (blue) and the substrate kaempherol (yellow) from the original VvGT1 x-ray structure (pdb 2C1Z [26]) are shown. Each subdomain is represented in the same color as in panel A. (C) Schematic of workflow for development of selective glucuronidation inhibitors. (D) UGT1A-C protein after purification by Coomassie blue stained SDS-PAGE gel. Molecular weight markers are shown.