Table 3.
Logistic Regression Models for the Odds of Higher Perceived Fatigability being associated with GMV/ICV Anatomical Brain Regions (The LIFE Study, N=29)
| Perceived Physical Fatigability | |||
|---|---|---|---|
| Model 1. | Model 2. | Model 3. | |
| Unadjusted | Adjusted for age | Adjusted for smoking status | |
| Region of Interesta | OR (95% CI) | OR(95% CI) | OR(95% CI) |
| Amygdala (L) | 0.60(0.26, 1.37) | 0.60(0.25, 1.44) | 0.62(0.27, 1.45) |
| Amygdala(R) | 0.72(0.39, 1.33) | 0.73(0.38, 1.38) | 0.82(0.41, 1.65) |
| Posterior Cingulate (R) | 1.02(0.48, 2.17) | 1.04(0.48, 2.24) | 0.92(0.41, 2.04) |
| Hippocampus(R) | 0.90(0.71, 1.13) | 0.90(0.71, 1.14) | 0.87(0.68, 1.12) |
| Putamen(R) | 0.91(0.76, 1.09) | 0.91(0.76, 1.09) | 0.94(0.77, 1.14) |
| Tdalamus(L) | 0.75(0.55, 1.01) | 0.75(0.55, 1.01) | 0.71(0.52, 0.99) |
| Tdalamus(R) | 0.75(0.55, 1.02) | 0.73(0.52, 1.03) | 0.72(0.52, 1.02) |
| Perceived Mental Fatigability | |||
| Model 1. | Model 2. | Model 3. | |
| Unadjusted | Adjusted for age | Adjusted for smoking status | |
| Region of Interesta | OR (95% CI) | OR(95% CI) | OR(95% CI) |
| Amygdala (L) | 0.41(0.16, 1.07) | 0.49(0.18, 1.30) | 0.39(0.13, 1.15) |
| Amygdala(R) | 0.50(0.24, 1.04) | 0.56(0.26, 1.17) | 0.61(0.27 1.36) |
| Posterior Cingulate (R) | 0.66(0.31, 1.42) | 0.71(0.31, 1.59) | 0.49(0.20, 1.19) |
| Hippocampus(R) | 0.87(0.68, 1.10) | 0.88(0.68, 1.12) | 0.81(0.62, 1.05) |
| Putamen(R) | 0.87(0.71, 1.06) | 0.85(0.66, 1.08) | 0.91(0.73, 1.14) |
| Tdalamus(L) | 0.72(0.53, 0.99) | 0.72(0.51, 1.01) | 0.65(0.44, 0.94) |
| Tdalamus(R) | 0.61(0.41, 0.91) | 0.64(0.42, 0.96) | 0.46(0.24, 0.87) |
Note. (OR) = Odds Ratio; (CI) = Confidence Interval; (L)=Left subcortical; (R)=Right subcortical; Bolded values denote p<0.05
a
Gray Matter Volume divided by Intracranial Volume multiplied by a factor of 100