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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Ecotoxicol Environ Saf. 2018 Dec 4;170:77–86. doi: 10.1016/j.ecoenv.2018.11.107

Figure 6: Proposed model for the induction of ER stress by AgNPs.

Figure 6:

(A) RAECs are exposed to AgNPs with a BC leading to interaction with the cell membrane. (B) 20 nm AgNPs localize in multivesicular bodies while 100 nm AgNPs are trafficked to the lysosome. (C) The detachment of proteins from AgNP biocorona occurs within the multi-vesicular bodies. (D) Proteins, possibly with a modified structure, are transported to the endoplasmic reticulum resulting in ER stress through the unfolded protein response.