Table 2.

List of Epigenetic Enzymes Involved in Amyotrophic Lateral Sclerosis.

Class	Enzyme	Activity in ALS	Reference
Histone Acetyltransferases	CBP/p300	Reduced activity when interacting with FUS	61
	ELP3	Required for neuronal communication and survival in Drosophila	63
Histone Deacetylases	HDAC1	Mislocalizes to cytoplasm in FUS ALS model	73
		Accumulation in nucleus is neuroprotective	74
	HDAC2	Levels decrease in spinal tissue of ALS patients	72
	HDAC6	Promotes SOD1 aggregation	76
		Overexpression is neuroprotective in mouse model	77
	HDAC11	Levels increase in the spinal tissue of ALS patients	72
	SIRT1	Levels increase in the muscles of a mutated SOD1 mouse model	75
	SIRT2	Levels decrease in motor neurons of a mutated SOD1 mouse model	75
	NAD+ *	Depletion leads to motor neuron degeneration	79
Histone Methyltransferases	PRMT1	Overexpression rescues neurite growth in FUS model	93
		Reduced methylation of H4R3, ultimately leading to gene silencing	94
	PRMT5	Genomic instability and R-loop formation	110
Chromatin Modifying	CHD2/Chd1	Inhibited by TDP-43, inhibited stress response required for neuronal survival	108
	POLR2A	Genomic instability and R-loop formation	110

^*Sirtuin cofactor involved in ALS pathology.