Table 2.
Class | Enzyme | Activity in ALS | Reference |
---|---|---|---|
Histone Acetyltransferases | CBP/p300 | Reduced activity when interacting with FUS | 61 |
ELP3 | Required for neuronal communication and survival in Drosophila | 63 | |
Histone Deacetylases | HDAC1 | Mislocalizes to cytoplasm in FUS ALS model | 73 |
Accumulation in nucleus is neuroprotective | 74 | ||
HDAC2 | Levels decrease in spinal tissue of ALS patients | 72 | |
HDAC6 | Promotes SOD1 aggregation | 76 | |
Overexpression is neuroprotective in mouse model | 77 | ||
HDAC11 | Levels increase in the spinal tissue of ALS patients | 72 | |
SIRT1 | Levels increase in the muscles of a mutated SOD1 mouse model | 75 | |
SIRT2 | Levels decrease in motor neurons of a mutated SOD1 mouse model | 75 | |
NAD+ * | Depletion leads to motor neuron degeneration | 79 | |
Histone Methyltransferases | PRMT1 | Overexpression rescues neurite growth in FUS model | 93 |
Reduced methylation of H4R3, ultimately leading to gene silencing | 94 | ||
PRMT5 | Genomic instability and R-loop formation | 110 | |
Chromatin Modifying | CHD2/Chd1 | Inhibited by TDP-43, inhibited stress response required for neuronal survival | 108 |
POLR2A | Genomic instability and R-loop formation | 110 |
Sirtuin cofactor involved in ALS pathology.