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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Circulation. 2019 Jan 15;139(3):313–321. doi: 10.1161/CIRCULATIONAHA.118.038261

TABLE 2. Targeting and Treatment Details.

ECG = Electrocardiography, VT = Ventricular Tachycardia, LV = Left ventricle, SBRT = Stereotactic Body Radiotherapy

Targeting data acquired at baseline (n) (%)
 Magnetic Resonance Imaging
 Nuclear imaging
 Electrocardiographic imaging
 12-lead ECG

9 (47.4)
19 (100)
19 (100)
19 (100)
Non-invasive Programmed Stimulation
 Median # of induced VT (range)
 Median Cycle length of induced VT (milliseconds) (range)

2 (1–5)
360 (230–690)
Target location (n) *
 Segments in Left Ventricle
  Anterior
  Lateral
  Inferior
  Septal
  Apex
  LV Summit
 Segments in Right ventricle


 5
 6
 6
 3
 4
 2
1
Median Target Volume (cc’s) (range)
 Gross target volume
 Internal target volume
 Planning target volume

25.4 (6.4–88.6)
31.0 (17.7–128.9)
98.9 (60.9–298.8)
Immobilization system (n) (%)
 Vacuum immobilization (Elekta BodyFIX)
 Abdominal compression (CDR FreedomX)

3 (15.8)
16 (84.2)
Stereotactic Body Radiotherapy technique
 Volumetric modulated arc therapy
 Fixed-field intensity modulated therapy

17(89.5)
2 (10.5)
Linear accelerator
 Varian TrueBeam
 Varian Edge

3 (15.8)
16 (84.2)
Median Stereotactic Body Radiotherapy beam-on time (min) (range) 15.3 (5.4–32.3)
*

Segments refers to inclusion of a location as part of targeting for SBRT. Multiple patients had targets that involved more than one segment, so total number adds up to greater than 19.

The target is referred to as the gross target volume (GTV). After outlining the GTV, an additional area around the GTV was added to account for internal motion of the GTV caused by breathing and cardiac motion, as assessed by review of the 4D‐CT. This is called the internal target volume (ITV). Finally, an additional safety margin of 5 mm was added to the ITV region for treatment planning to create a planning target volume (PTV), which accounts for any residual uncertainties in patient setup, motion, and delivery.