Figure 2. Workflow of Synthetic Image Generation.

The generation of synthetic images is represented visually. The selected patient’s pre-treatment image is deformed by the inter-patient variation model to generate the synthetic pre-treatment images (highlighted in pink). For each of the synthetic pre-treatment images, four synthetic post-treatment images (highlighted in blue) are generated by deforming the synthetic pre-treatment image using the intra-patient variation model. (Reproduced with permission from Wiley ²⁴.)