Table 4. Sex-stratified genetic association of FCGR2A (rs1801274) with KD in KD subgroups after excluding iKD and ≥5 years old.
KD groups | Subgroups | Male | Female | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Number | RAF* | OR | 95% CI | p† | Number | RAF* | OR | 95% CI | p† | ||
All | 474 | 0.826 | 1.52 | 1.26–1.82 | 4.50×10−6 | 315 | 0.792 | 1.20 | 0.98–1.46 | 0.0819 | |
Age (years) | 0 to <1 | 117 | 0.872 | 2.17 | 1.47–3.21 | 6.69×10−5 | 66 | 0.795 | 1.22 | 0.80–1.87 | 0.358 |
1 to <2 | 102 | 0.784 | 1.16 | 0.83–1.64 | 0.388 | 73 | 0.801 | 1.27 | 0.84–1.91 | 0.258 | |
2 to <3 | 111 | 0.826 | 1.50 | 1.05–2.14 | 0.0238 | 69 | 0.790 | 1.18 | 0.78–1.79 | 0.432 | |
3 to <4 | 88 | 0.826 | 1.49 | 1.01–2.22 | 0.0447 | 66 | 0.758 | 0.98 | 0.66–1.47 | 0.928 | |
4 to <5 | 56 | 0.812 | 1.39 | 0.86–2.24 | 0.182 | 41 | 0.829 | 1.53 | 0.86–2.72 | 0.150 |
CI = confidence interval; FCGR2A = Fc gamma receptor II a; iKD = incomplete type of Kawasaki disease; KD = Kawasaki disease; OR = odds ratio; RAF = risk allele frequency.
*The RAFs (risk allele: A; non-risk allele: G) for FCGR2A were 0.758 and 0.761 for the male and female controls, respectively; †The p<0.05 was considered significant and is denoted in bold.